TABLE 2. Clin. gastroenterology 28 (4), 448–451. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, signs of kidney problems (such as change in the amount of urine). Inform patients that this drug may cause dizziness or blurred vision, and they should avoid driving or operating machinery if these side effects occur. Gut 59 (8), 1143–1153. A follow-up study. (2019). doi:10.1111/hel.12475, Malfertheiner, P., Megraud, F., O'Morain, C. A., Gisbert, J. P., Kuipers, E. J., Axon, A. T., et al. Do not crush or chew the granules. 31 (9), 44–47. Received: 11 November 2022; Accepted: 23 January 2023;Published: 01 February 2023. Pract. Diagnosis. Do not mix with other foods or liquids. Sensitivität bedeutet, dass der betreffende Labortest mit hoher Wahrscheinlichkeit ein richtig positives Ergebnis . Helicobacter pylori (H. pylori) infection and related diseases are a major global health concern. Eur. This study was supported by grants from the National Natural Science Foundation of China (No. This drug may be used concomitantly with antacids without affecting the absorption. Second, we did not measure the patients’ intragastric pH value or CYP2C19 genotype. A very serious allergic reaction to this drug is rare. Gastroenterological Assoc. To take it by mouth, open the packet and mix the granules in applesauce or apple juice. Several studies have tested the effect of a total daily dose of amoxicillin on the cure rate. Prevacid OTC . Adv. (Leung et al., 2018) demonstrated that among patients infected with H. pylori who received eradication therapy, the gastric cancer risk was significantly lower in the elderly compared with the matched general population highlighting the importance of eradication therapy for elderly patients. Pantoprazole and bismuth were taken 30 min before breakfast and dinner, and amoxicillin and clarithromycin were taken 30 min after breakfast and dinner. Peptic ulcer. To help you remember, take it at the same time each day. Der Test basiert auf zwei spezifischen monoklonalen Antikörpern gegen H . Hallo Kathrin Wie Frau Doktor schon sagte, ist keine Behandlung nötig. Adverse events occurred in 10.6% (8/75) of patients, which was similar to most reports (Tai et al., 2019; Zou et al., 2021). alcohol abuse (daily alcohol intake exceeding 50 G for more than 6 months); 4). Ich würde mich der Nebenwirkungen der Tabletten besonders des Antibiotikum nicht antun. Aim: To perform a systematic review on the efficacy of pantoprazole based therapies in Helicobacter pylori eradication, and to conduct a meta-analysis comparing the efficacy of pantoprazole and other proton pump inhibitors (PPIs) when co-prescribed with antibiotics. The study protocol was approved by the Institutional Ethics Board of the First Affiliated Hospital of Nanchang University, Nanchang, China (No. J. gastroenterology hepatology 32 (5), 563–568. Proton pump inhibitors (such as pantoprazole) may increase your risk for bone fractures, especially with longer use, higher doses, and in older adults. However, there is currently no consensus or guideline on H. pylori eradication therapy in elderly patients. Consult your doctor before breast-feeding. Take your next dose at the regular time. doi:10.1097/MD.0000000000014396, Yu, L., Luo, L., Long, X., Liang, X., Ji, Y., Graham, D. Y., et al. If it is near the time of the next dose, skip the missed dose. The compliance rates was 98.7% (74/75) in the HT group and 97.3% (73/75) in the BQT group. A product that may interact with this drug is: methotrexate (especially high-dose treatment). J. In the BQT group, the frequency of side effects was 26.6% (20/75) of patients (p = 0.026). During pregnancy, this medication should be used only when clearly needed. Side effects were few although a minority of patients in the BQT group complained of vomiting due to clarithromycin. Copyright © 2023 Yang, He, Hu, Hong, Zhu, Xie, Shu, Lu and Zhu. Our results showed that both regimens achieved a successful eradication rate, and HT with pantoprazole and amoxicillin was efficient with a rate of 93.0% in the PP analysis, 91.7% in the mITT analysis and 89.3% in the ITT analysis. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool. Optimized high-dose amoxicillin-proton-pump inhibitor dual therapies fail to achieve high cure rates in China. The BQT consisted of pantoprazole 40 mg twice daily, amoxicillin 1,000 mg twice daily, clarithromycin 500 mg twice daily, and bismuth 220 mg twice daily for 14 days. 4. If you are taking the granules, take your dose 30 minutes before a meal. Short-term treatment of gastroesophageal reflux disease (GERD) in patients with a history of erosive esophagitis, Reduction of relapse rates of daytime and nighttime heartburn symptoms in adult patients with GERD, Initial dose: 80 mg via IV infusion every 12 hours, given over at least 2 minutes OR over 15 minutes, Maintenance dose: 80 mg via IV infusion every 8 to 12 hours, given over at least 2 minutes OR over 15 minutes. 16 (9), 1427–1433. Based on a previous study, we estimated the eradication rate of the BQT groups to be 89.7% (Yang et al., 2019a). Urinate into the toilet if needed . (2021). (2016). Efficacy of modified esomeprazole-amoxicillin dual therapies for Helicobacter pylori infection: An open-label, randomized trial. This medication passes into breast milk. 0. Gastroenterol. doi:10.1111/1751-2980.12186, Salles, N., and Mégraud, F. (2007). 114 (3), 437–445. 40 kg and greater: 40 mg orally once a day 9 studies conducted in China and published in the last 5 years. Results: Successful eradication was achieved in 89.3% of the high-dose dual therapy (HT) group in the intention-to-treat (ITT) analysis, 91.7% in the modified intention-to-treat (mITT) analysis, and 93.0% for per-protocol (PP) analysis which was similar to the bismuth-containing quadruple therapy (BQT) group (86.6%, 87.8%, and 90.3%, respectively). No use, distribution or reproduction is permitted which does not comply with these terms. Gut 65 (11), 1784–1792. Controlled studies using the oral formulation for maintenance did not extend beyond 12 months. Pract. No adjustment recommended. Fifth Chinese national consensus report on the management of Helicobacter pylori infection. Pharmacol. doi:10.1136/gut.2009.192757, Graham, D. Y., Javed, S. U., Keihanian, S., Abudayyeh, S., and Opekun, A. R. (2010). Gastroenterology 155 (1), 67–75. Symptomatic relief may occur after 1 day of treatment, but patients should continue treatment for the full duration to achieve complete symptom control. Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur. The prevalence of upper gastrointestinal diseases is increasing in elderly populations worldwide. If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse. High-dose PPI-amoxicillin dual therapy with or without bismuth for first-line Helicobacter pylori therapy: A randomized trial. There have also been several dual-therapy studies conducted in China, and most of them show successful eradication rates with fewer adverse events (Hu et al., 2017; Tai et al., 2019; Gao et al., 2020b; Song et al., 2020; Zhang et al., 2020; Zou et al., 2021; Shen et al., 2022) (Table 4). The trial was registered in the Chinese Clinical Trials Registration (chictr.org.cn), registered number is ChiCTR2000029679. doi:10.1093/jac/dkz046, Unge, P., Gad, A., Gnarpe, H., and Olsson, J. Pantoprazole is used to treat certain stomach and esophagus problems (such as acid reflux). Individual treatment needs to be performed in elderly patients. A proton pump inhibitor (PPI) and the antibiotics clarithromycin and amoxicillin/metronidazole, the so-called standard triple therapy, are used as the first-line eradication therapy for H. pylori infection, worldwide (Salles and Mégraud, 2007). CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Zegerid OTC . In the HT group, 2 patients were lost to follow-up, and 1 paytient was not compliant with medications. J. Clin. clinically significant liver or kidney insufficiency (transaminase greater than 1.5 times the upper limit of normal, or serum creatinine greater than the upper limit of normal; 6). In general, elderly patients show a low tolerance and compliance to H. pylori eradication therapy (Salles and Mégraud, 2007). Uses. Tell your doctor if your condition lasts or gets worse. H. PYLORI BREATH TEST Patient Instructions STOP 2 WEEKS BEFORE YOUR TEST: PROTON PUMP INHIBITORS (PPI) Dexilant . We comply with the HONcode standard for trustworthy health information. The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors. doi:10.14309/ajg.0000000000000132, Yang, J. C., Lin, C. J., Wang, H. L., Chen, J. D., Kao, J. Y., Shun, C. T., et al. 74 (6), 1718–1724. H. pylori eradication was evaluated by a 13C-urea breath test 4 weeks after the completion of treatment. WebMD does not provide medical advice, diagnosis or treatment. If you are giving the granules through a tube into the stomach (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to properly mix and give it. jxsq2019201028). Although dual therapy is not currently recommended as the first-line regimen for treating H pylori infection, many studies have reported an effective eradication rate of this regimen (Ren et al., 2014; Yang et al., 2015; Tai et al., 2019). The H. pylori breath test involves breathing into a balloon-like bag. Suppl. Testing is important for detection of Helicobacter pylori (H. pylori). jxsq2019201028) this writing assistance. We investigated whether high-dose dual therapy would serve as the first-line therapy in elderly patients. In May 2023, Frontiers adopted a new reporting platform to be Counter 5 compliant, in line with industry standards. CYP450 2C19 Poor Metabolizers: Exp. The PPI potency has a strong ability to reliably maintain a relatively high intragastric pH. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Eradication rates in each regimen. Once H. pylori has been . However, studies from the different regions show different cure rates, probably due to different dosages of PPI and amoxicillin (Graham et al., 2010; Kwack et al., 2016; Park et al., 2017). Patients should be told that treatment may not provide immediate relief and that they should not take this drug for prophylaxis. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Tests may be done using a stool sample, through a breath test and by an upper endoscopy exam. High dose dual therapy versus bismuth quadruple therapy for Helicobacter pylori eradication treatment: A systematic review and meta-analysis. A pilot study. This single-center, prospective, open-label, randomized controlled trail was conducted at the First Affiliated Hospital of Nanchang University, Nanchang, China. Medicine 98 (7), e14396. If you are taking the tablets, you may take them with or without food. Our study had some limitations. doi:10.1097/MEG.0000000000001646, Zhu, Y. J., Zhang, Y., Wang, T. Y., Zhao, J. T., Zhao, Z., Zhu, J. R., et al. Successful eradication was achieved in 10 of these patients. Ther. Evaluation of different proton pump inhibitors combined with bismuth quadruple regimens in Helicobacter pylori eradication. Reflux symptoms may take 2 to 3 days to improve after initiation. Uses: IV: Data not available 20 (4), 609–614. Jetzt habe ich gelesen, dass es sein kann, dass das Bekterium auf Grund des Medikamentes nicht im Stuhl gefunden werden kann und der Test somit falsch negativ sein kann. This is not a complete list of side effects and others may occur. Helicobacter 23 (2), e12475. (2019). Veröffentlicht: 25.03.2009, 05:00 Uhr. Er ist ein immunologischer Schnelltest, mit dem über eine spezifische Antikörperreaktion H.pylori Antigen in Stuhlproben nachgewiesen werden kann. Talk to your pharmacist for more details. Nausea, diarrhea, and abdominal pain were the most frequently occurring adverse events. Pantoprazole belongs to a class of drugs known as proton pump inhibitors (PPIs). Rapid acid control may be achieved within an hour at an IV dose of 160 mg. HEPATIC: Liver function tests, especially in patients with impaired liver function, METABOLIC: Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy; Vitamin B12 levels, especially in patients on long-term therapy, MUSCULOSKELETAL: Bone fractures, especially in patients at high-risk for osteoporosis-related events. Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: Studies from the United States. In the mITT analysis, H. pylori were eradicated in 91.7% of patients (67/73) (95% Cl:85.3–98.2) in the HT group compared with 87.8% (65/74) (95% Cl:80.2–95.5) in the BQT group (Table 2). Moreover, the risk of adverse effects of H. pylori eradication therapy increases in elderly patients. Talk with your doctor or pharmacist about ways to prevent bone loss/fracture, such as by taking calcium (such as calcium citrate) and vitamin D supplements. Peptic ulcers are currently the main impact of H. pylori on healthcare resources, and older patients are at the greatest risk, as the mortality rate from peptic ulcers increases from approximately 1 in 100 000 at age 20 to 2-3 in 100 000 at age 70 (Bank et al., 1986). Dig. Res. Helicobacter 26 (4), e12816. The HT consisted of pantoprazole 40 mg 3 times daily and amoxicillin 1,000 mg 3 times daily for 14 days. Stuhltest auf Helicobacter pylori. *Correspondence: Nonghua Lu, lunonghua@ncu.edu.cn; Yin Zhu, zhuyin27@sina.com.cn, †These authors have contributed equally to this work, https://doi.org/10.3389/fphar.2023.1096103. Some studies have shown that the drug resistance of the bismuth quadruple regimen after eradication failure is significantly higher than that of the dual therapy (Ren et al., 2014). 5 Add stool to the "FILL LINE".T ighten cap securely.. 2 : Lift toilet seat. Medically reviewed by Drugs.com. Ren, L., Lu, H., Li, H. Y., Zhu, L. Y., Xu, X. Q., Gu, L. Y., et al. There were no significant difference in the eradication rates in the ITT, mITT, and PP analysis between the 2 treatment groups. Pathological Hypersecretion (including Zollinger-Ellison syndrome): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. doi:10.1053/j.gastro.2018.03.028, Li, C., Shi, Y., Suo, B., Tian, X., Zhou, L., and Song, Z. Equivalent efficacies of reverse hybrid and bismuth quadruple therapies in eradication of Helicobacter pylori infection in a randomized controlled trial. An improvement in acid inhibition extending into the nighttime hours, maintaining an intragastric pH of 6 or above, would greatly improve the eradication rates of a regiment (Marcus et al., 2012). This medication relieves symptoms . Lancet (London, Engl. The studies involving human participants were reviewed and approved by the First affiliated hospital of Nanchang university. doi:10.2217/pgs-2020-0127, Gao, C. P., Zhang, D., Zhang, T., Wang, J. X., Han, S. X., Graham, D. Y., et al. In Canada - Call your doctor for medical advice about side effects. Many people using this medication do not have serious side effects. Call your doctor for medical advice about side effects. Clin. doi:10.1080/07853890.2022.2031269, Song, Z., Zhou, L., Xue, Y., Suo, B., Tian, X., and Niu, Z. Rarely, proton pump inhibitors (such as pantoprazole) have caused vitamin B-12 deficiency. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. gastroenterology 2004 18, 73–81. Diagnostic tests used in the primary care office include serology and stool antigen tests, whereas the urea breath test and gastric biopsies require subspecialist referral. Gastroenterology Res. Current management of Helicobacter pylori infections in the elderly. Things to remember when you fill your prescription. This medication relieves symptoms such as heartburn, difficulty swallowing, and cough. Adults: No adjustment recommended. The pantoprazole-based eradication program was less affected by the CYP2C19 polymorphism (Fu et al., 2021). (2020). You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. 167, 49–54. Re: helicobacter lt. stuhltest postiv lt. Magenspiegelung negativ. HT was associated with fewer side effects (10.6% of patients) than BQT (26.6%) (p = 0.026). Our study followed the recommendations of the Consolidated Standards of Reporting Trials (CONSORT) statement for reporting randomized controlled trials. The chi-square test was used to determine the significance of differences between categorical variables and the t-test were used for continuous variables. If patients are not healed after 8 weeks or erosive esophagitis (EE) recurs with the oral formulation, treatment for another 8 weeks may be considered. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Zullo, A., Ridola, L., Francesco, V. D., Gatta, L., Hassan, C., Alvaro, D., et al. The globally increasing antibiotic resistance in recent years is an important cause of first-line H pylori eradication failure (Graham and Fischbach, 2010). Rabeprazole and esomeprazole were the most commonly used PPIs in these studies. Some affected products include ampicillin, atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others. Pantoprazole vs. omeprazole: What's the difference between them? Do not over-fill the container. Therefore, it is of practical significance to develop a safe and effective H. pylori eradication program for elderly patients, which is worthy of further study. Treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, Pathological hypersecretion conditions, including Zollinger-Ellison syndrome, Short-term treatment of GERD in patients with a history of EE, Acid output target range: Less than 10 mEq/h, Hypersensitivity to the active component, substituted benzimidazoles, or any of the ingredients, Patients receiving rilpivirine-containing products. The distribution of patients according to sex, symptoms, and mean age is shown in Table 1. Therefore, the regimen of 40 mg pantoprazole plus 3 g amoxicillin per day may be a favorable choice for elderly patients. Variety of adverse events in each regimen. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Die meisten kommerziellen Testsysteme haben eine halbwegs gute Sensitivität (93,3%) sowie Spezifität (93,9%) für den Nachweis dieser Infektionen, wobei. This medication may interfere with certain laboratory tests (including urine test for tetrahydrocannabinol-THC, blood test to find certain tumors), possibly causing false test results. (2017). J. Gastroenterol. Expert Rev. Therefore, we questioned whether high-dose and high-frequency amoxicillin-PPI dual therapy could be widely used in elderly patients. Does Pantoprazole SODIUM interact with other drugs you are taking? For patients unable to swallow a 40 mg tablet, two 20 mg tablets may be taken; however, the 40 mg oral suspension packet formulation should not be divided to create two-20 mg dosages. Get medical help right away if you have: heartburn with lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), unexplained weight loss. Helicobacter 24, e12596. OTC Medications: Are You Taking Too Much? 8217033301) for and grants from the Double-Thousand Plan of Jiangxi Province (No. Demographic and clinical data of patients. Nexium . Pantoprazole decreases stomach acid, so it may change how well these products work. Dis. High-dose esomeprazole and amoxicillin dual therapy for first-line Helicobacter pylori eradication: A proof of concept study. doi:10.1016/j.cgh.2018.03.031, Hu, J. L., Yang, J., Zhou, Y. (2014). TABLE 1. There is evidence that a dose of 3 g per day can achieve an effective eradication rate (Kwack et al., 2016; Li et al., 2021). High dose PPI-amoxicillin dual therapy for the treatment of Helicobacter pylori infection: A systematic review with meta-analysis. However, according to some recent literature reports, increasing the dose of PPI and/or amoxicillin in the dual therapy regimen can effectively eradicate H. pylori (Goh et al., 2012; Attumi and Graham, 2014; Yang et al., 2015; Yu et al., 2019). (2018). Methods: This was a single-center, randomized study of 150 elderly patients with H. pylori infection who were randomly assigned to 14-day therapy with pantoprazole 40 mg 3 times daily and either amoxicillin 1,000 mg 3 times daily or amoxicillin 1,000 mg twice daily, clarithromycin 500 mg twice daily and bismuth 220 mg twice daily. pantoprazole 20 mg tablet,delayed release. Ann. 15 to less than 40 kg: 20 mg orally once a day Elderly patients generally have renal or liver dysfunction, which might affect drug accumulation. male or female patients aged ≥60 years; 2) patients diagnosed with H. pylori infection by positive C-urea breath test (UBT) or by positive gastric mucosa biopsy results (UBT results between 4‰ and 6‰ were not included in the group, as well as those who remained above 4‰ after 7 days of reexamination); 3). Am. gastroenterology 8 (32), 381–384. The Fifth Chinese National Consensus Report on management highly recommends that patients with peptic ulcers receive eradication of H. pylori (Liu et al., 2018). Allerdings hatte er mir einige Tage zuvor Pantoprazol verschrieben. doi:10.1111/hel.12496, Yang, J., Zhang, Y., Fan, L., Zhu, Y. J., Wang, T. Y., Wang, X. W., et al. In aition, other factors influence the efficacy of treating H. pylori infection. The eradication rate of H. pylori was calculated using intention-to-treat (ITT), modified intention-to-treat (mITT), and per-protocol (PP) analyses together with a 95% confidence interval (CI). Am. (2013). Use of the IV formulation for longer than 6 days and/or with doses higher than 240 mg has not been adequately studied. fever, rash, or cold symptoms (most common in children). High and frequent dose of dexlansoprazole and amoxicillin dual therapy for Helicobacter pylori infections: A single arm prospective study. In this respect, some meta-analyses showed higher HT effectiveness in studies in Asian countries than in European countries (Yang et al., 2019b; Gao et al., 2020a; Zhu et al., 2020). In this study, we used 40 mg pantoprazole which is relatively unaffected by CYP2C19 metabolism. Keywords: bismuth, dual therapy, elderly patients, eradication, Helicobacter pylori, Citation: Yang Q, He C, Hu Y, Hong J, Zhu Z, Xie Y, Shu X, Lu N and Zhu Y (2023) 14-day pantoprazole- and amoxicillin-containing high-dose dual therapy for Helicobacter pylori eradication in elderly patients: A prospective, randomized controlled trial. This condition may occur during treatment or weeks to months after treatment has stopped. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Approximately 44% of the global population is infected with H. pylori (Malfertheiner et al., 2017). pantoprazole 40 mg tablet,delayed release, Select a condition to view a list of medication options. doi:10.1586/14787210.5.5.845, Shen, C., Li, C., Lv, M., Dai, X., Gao, C., Li, L., et al. J. H. pylori infection is a major cause of peptic ulcer disease. doi:10.1111/hel.12816, Liou, J. M., Chen, C. C., Chang, C. Y., Chen, M. J., Chen, C. C., Fang, Y. J., et al. This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. doi:10.1097/00004836-198606002-00010, Fu, J., Sun, C. F., He, H. Y., Ojha, S. C., Shi, H., Deng, C. L., et al. Scand. Ein positiver Helicobacter-pylori-Schnelltest im Stuhl bedeutet einen Hinweis auf eine Infektion mit Helicobacter pylori. © 2005 - 2023 WebMD LLC, an Internet Brands company. Patients may be vulnerable to increased acid production despite a short period of loss of effective inhibition. Sprinkle the granules on 1 teaspoon (5 milliliters) of applesauce and swallow all of the mixture right away (within 10 minutes). Helicobacter pylori treatment in the era of increasing antibiotic resistance. Tablet formulations should be swallowed whole, without crushing/chewing; tablets may be taken with or without food. Several tests and procedures are used to determine whether you have H. pylori infection. Best Pract. Der H. pylori Stuhl Test ist ein visueller Immunoassay für den qualitativen Nachweis von H. pylori Antigen in Stuhlproben. doi:10.1111/hel.12126, PubMed Abstract | CrossRef Full Text | Google Scholar, Bank, L., Wright, J. P., Lucke, W., and Marks, I. N. (1986). Applies to the following strengths: 40 mg; 20 mg. 5 years and older: To make sure you take the entire dose, rinse the cup once or twice with apple juice to mix any remaining granules, and swallow the juice. doi:10.1016/S0140-6736(12)61579-7, Liu, W. Z., Xie, Y., Lu, H., Cheng, H., Zeng, Z. R., Zhou, L. Y., et al. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The exclusion criteria were as follows: 1). Enter your medication into the WebMD interaction checker. 70 (4), 176–180. Und wenn dann kann ich nur empfehlen Hefekapseln für die Darmflora zu nehmen, denn durch das Antibiotikum werden auch gute Bakterien abgetötet. Several meta-analyses have compared the efficacy and safety of dual therapy and other regimens, and all of them concluded that PPI-amoxicillin is equally effective as other commonly used therapeutic regimens in the eradication of H. pylori (Gao et al., 2020a; Li et al., 2021). Flow diagram of this study. Written informed consent was obtained from all participants. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Pilotto, A. Management of Helicobacter pylori infection-the maastricht V/florence consensus report. Side effects were graded according to their influence on daily life, classified as “mild” (transient and well-tolerated), “moderate” (discomfort that partially affected daily life), or “severe” (severe interruption of daily activities). Properly discard this product when it is expired or no longer needed. Otherwise, call a poison control center right away. Doing so may destroy the drug. Use this medication regularly to get the most benefit from it. The granule formulation may be sprinkled into applesauce or mixed into a small volume of either apple juice or orange juice and swallowed immediately. B., Li, P., Han, R., and Fang, D. C. (2017). (2020). Maximum dose: 240 mg/day. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lupus. There were no significant difference between the two groups regarding clinical characteristics. Helicobacter 25 (6), e12762. PPI-Amoxicillin dual therapy four times daily is superior to guidelines recommended regimens in the Helicobacter pylori eradication therapy within asia: A systematic review and meta-analysis. High-dose extended-release lansoprazole (dexlansoprazole) and amoxicillin dual therapy for Helicobacter pylori infections. Furazolidone-containing triple and quadruple eradication therapy for initial treatment for Helicobacter pylori infection: A multicenter randomized controlled trial in China. doi:10.4166/kjg.2017.70.4.176. Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: A multicentre, open-label, randomised trial. Med. If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate. This was also a single-center study. (2019). In conclusion, our data showed that a 14-day regimen with pantoprazole 40 mg 3 times daily and amoxicillin 1,000 mg 3 times daily achieved an H. pylori eradication rate of 89.3%. Background: Short-term, low-dose triple regimens composed of proton-pump inhibitors (PPI) and two antibiotics are the current gold standard therapy for cure of Helicobacter pylori infection. Rabeprazole-amoxicillin dual therapy as first-line treatment for H pylori eradication in special patients: A retrospective, real-life study. In China, the rural population accounts for the main proportion of patients with H. pylori infection. Selected from data included with permission and copyrighted by First Databank, Inc. Follow with sips of water. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medicine is a yellow, oval, enteric-coated, tablet imprinted with "H125". Some comments on the heterogeneity of the results with HT should be included. (2020). The HT was generally well tolerated by patients. Alimentary Pharmacol. Short-term treatment in the healing and symptomatic relief of EE. Guten Tag, mein Arzt vermutet mittlerweile bei mir eine Magenbesiedlung mit Helicobacter Bakterien.Um dies herauszufinden, hat er eine Stuhlprobe genommen.
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